Table 2.
Mean characteristics of treatment during follow-up
| Characteristic | Online Hemodiafiltration | Low-Flux Hemodialysis | Mean Difference (SEM) | P Value for Difference |
|---|---|---|---|---|
| Duration of dialysis session (h) | 3.77 (0.01) | 3.81 (0.01) | −0.04 (0.02) | 0.02 |
| Blood flow (ml/min) | 332 (2.6) | 312 (2.3) | 20 (3.4) | 0.001 |
| Sessions/wk (n) | 2.99 (SD 0.6) | 2.99 (SD 0.7) | 0.002 (0.02) | 0.25 |
| Online hemodiafiltration | ||||
| number of sessions/wka | 2.71 (SD 0.35) | NA | ||
| convection volume (L)/treatment | 20.7 (SD 6.0) | NA | ||
| Single-pool Kt/Vurea | 1.63 (0.02) | 1.45 (0.02) | 0.18 (0.03) | <0.001 |
| β-2-microglobulin (mg/L) | 26.4 (0.37) | 35.4 (0.54) | −8.9 (0.7) | <0.001 |
| Albumin (g/L) | 39.4 (0.14) | 39.7 (0.15) | −0.30 (0.20) | 0.14 |
| CRP (mg/L) | 11.9 (1.4) | 11.4 (1.2) | 0.52 (1.9) | 0.77 |
| Hemoglobin (g/dl) | 11.8 (0.03) | 11.6 (0.03) | 0.11 (0.05) | 0.03 |
| Phosphorus (mg/dl) | 4.80 (0.06) | 4.95 (0.06) | 0.19 (0.06) | 0.02 |
| Cholesterol (mg/dl) | 143 (2) | 139 (2) | 2 (2) | 0.28 |
| Predialysis systolic pressure (mmHg) | 146 (1) | 145 (1) | 0.9 (0.5) | 0.49 |
| Interdialytic weight change, pre − post (kg) | 1.91 (0.05) | 1.85 (0.05) | 0.05 (0.07) | 0.51 |
Average levels during the trial and mean difference over time between treatment arms obtained through GEE analyses using the on trial measurements with adjustments for baseline measurements. Values are means (SEM) unless otherwise indicated. NA, not applicable; CRP, C-reactive protein.
a
Actual number of sessions per week delivered as online hemodiafiltration during the trial, the other sessions were delivered as high-flux hemodialysis.