Table 4.

Risk of all-cause mortality and fatal and nonfatal cardiovascular events by achieved convection volume in liters per treatment

	Hemodialysis	Online Hemodiafiltration Convection Volume Tertiles			P for Trend
		<18.17 L	18.18–21.95 L	>21.95 L
Total mortality
crude	1.0	0.95 (0.66–1.38)	0.83 (0.57–1.22)	0.62 (0.41–0.93)	0.010
adjusteda	1.0	0.79 (0.53–1.14)	0.77 (0.51–1.14)	0.65 (0.42–0.99)	0.012
adjustedb	1.0	0.80 (0.52–1.24)	0.84 (0.54–1.29)	0.61 (0.38–0.98)	0.015
Fatal and nonfatal cardiovascular events
crude	1.0	1.37 (0.94–1.98)	1.06 (0.72–1.56)	0.76 (0.50–1.16)	0.473
adjusteda	1.0	1.41 (0.92–2.11)	0.93 (0.62–1.40)	0.77 (0.48–1.21)	0.369
adjustedb	1.0	1.35 (0.86–2.11)	1.04 (0.66–1.62)	0.72 (0.44–1.19)	0.475

Results reported as HR and 95% confidence interval, from Cox proportional hazards models. Reference is treatment with low-flux hemodialysis.

^aAdjusted for determinants of mortality, i.e., age, sex, previous vascular disease, diabetes, previous transplantation, spKt/V, baseline eGFR, baseline albumin, baseline creatinine, baseline hematocrit, and use of α- and β-blockers, calcium antagonists, and angiotensin converting inhibitors at baseline (82 missing, 206 deaths, 182 cardiovascular events).

^bAdjusted for the above-mentioned determinates as well as for center differences (82 missing, 206 deaths, 182 cardiovascular events).