Table 2.
Surrogate indices of fluid and nutritional status and selected medication usage in balANZ trial participants over a 2-year period
| Variable | 0 mo | 3 mo | 6 mo | 12 mo | 18 mo | 24 mo | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Balance | Stay.safe | Balance | Stay.safe | Balance | Stay.safe | Balance | Stay.safe | Balance | Stay.safe | Balance | Stay.safe | |
| (n=91) | (n=91) | (n=85) | (n =80) | (n=76) | (n=75) | (n=62) | (n=66) | (n=53) | (n=59) | (n=42) | (n=48) | |
| Systolic BP (mmHg), supine | 139.8±21.4 | 138.9±21.8 | 134.9±20.0 | 134.8±21.6 | 133.6±19.7 | 131.0±22.5 | 131.7±20.8 | 130.8±22.3 | 132.4±18.7 | 132.9±22.3 | 127.0±16.3a | 137.8±24.2 |
| Diastolic BP (mmHg), supine | 76.6±11.3 | 78.1±11.0 | 76.6±12.7 | 76.6±13.5 | 75.1±13.2 | 74.5±14.4 | 75.2±13.3 | 74.3±10.5 | 74.2±12.2 | 75.2±12.7 | 72.3±12.4 | 75.4±13.8 |
| MAP (mmHg), supine | 96.7±12.4 | 97.4±12.5 | 95.1±13.1 | 95.1±14.1 | 93.6±13.4 | 92.4±15.3 | 93.1±13.7 | 92.2±13.0 | 92.7±12.4 | 93.5±13.9 | 89.6±11.8 | 95.3±15.4 |
| Actual weight (kg) | 76.3±16.5 | 76.8±18.9 | 77.8±17.3 | 76.8±18.1 | 79.3±17.9 | 78.3±18.6 | 81.9±18.3 | 79.4±19.1 | 84.1±18.7 | 80.8±19.2 | 83.2±19.8 | 82.1±19.0 |
| Physician-assessed dry weight (kg) | 76.2±16.6 | 75.6±18.2 | 77.7±17.3 | 77.0±17.8 | 79.4±18.0 | 78.1±18.6 | 81.9±18.3 | 79.9±18.8 | 84.4±18.7 | 80.8±19.5 | 83.5±20.1 | 82.1±19.0 |
| Hemoglobin (g/L) | 115±17 | 115±17 | 118±16 | 122±16 | 122±15 | 121±17 | 120±15 | 118±15 | 117±12 | 117±13 | 116±14 | 116±13 |
| Serum albumin (g/L) | 38±5 | 37±6 | 34±5 | 35±5 | 35±8 | 35±5 | 34±4 | 35±5 | 34±5 | 35±5 | 32±5a | 34±5 |
| Serum sodium (mmol/L) | 140±3 | 139±3 | 139±3 | 139±3 | 138±4 | 138±4 | 138±4 | 138±4 | 138±3 | 138±4 | 137±4 | 138±3 |
| Urine volume (ml/d) | 1556±691 | 1501±682 | 1228±674a | 991±685 | 1150±614a | 923±700 | 1081±656 | 731±573 | 957±822 | 754±743 | 814±624 | 699±639 |
| 24-h dialysate peritoneal ultrafiltration (ml/d) | ND | ND | 763±724a | 1105±625 | 811±588a | 1107±856 | 943±687 | 1196±748 | 1024±632 | 1002±873 | 1070±689 | 1009±762 |
| 24-h dialysate fill volume (ml/d) | 7198±1598 | 7137±1591 | 7506±1198 | 7758±1727 | 7676±1573 | 8228±2204 | 8036±1461 | 8602±1927 | 8503±1593 | 8623±1885 | 8569±1956 | 8928±2125 |
| Daily prescribed glucose exposure (g/d) | 121.5±35.3 | 123.6±36.3 | 142.1±43.5 | 133.9±36.9 | 143.7±40.5 | 140.5±43.5 | 150.0±41.0 | 150.9±48.5 | 158.4±49.2 | 150.2±50.5 | 161.7±54.1 | 157.4±52.3 |
| Urinary creatinine excretion (mmol/d) | 8.1±3.0 | 7.8±3.5 | 6.8±3.2 | 6.4±3.8 | 6.5±2.8 | 5.9±3.0 | 6.2±2.8 | 5.3±3.3 | 5.5±3.2 | 5.3±3.6 | 5.0±3.0 | 5.1±3.4 |
| Normalized protein nitrogen appearance (g/kg body wt per d) | ND | ND | ND | ND | 1.05±0.35 | 1.06±0.26 | 1.00±0.21 | 1.04±0.33 | 0.99±0.22 | 1.02±0.28 | 1.02±0.31 | 1.02±0.24 |
| ACE inhibitor | 40 (44) | 45 (45) | 34 (40) | 33 (41) | 30 (39) | 29 (39) | 23 (37) | 27 (41) | 19 (36) | 24 (41) | 14 (33) | 20 (42) |
| ARB | 25 (28) | 29 (32) | 24 (48) | 21 (26) | 21 (28) | 17 (23) | 19 (31) | 15 (23) | 15 (28) | 13 (22) | 12 (29) | 10 (21) |
| NSAID | 4 (4) | 2 (2) | 2 (2) | 1 (1) | 2 (3) | 1 (1) | 2 (3) | 1 (2) | 4 (8) | 1 (2) | 3 (7) | 0 (0) |
Results are presented as number (%), mean ± SD, or median (range). MAP, mean arterial pressure; ND, not done; ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; NSAID, nonsteroidal anti-inflammatory drug.
a
P<0.05 versus stay.safe.