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vWF binding to smooth muscle cells. Rat aortic smooth muscle cells (A7R5) were incubated with purified, infrared-tagged human vWF at varying concentrations to assess binding. Binding to cells increased in a dose dependent fashion (A). Unlabeled vWF, but not recombinant Fc protein, competed against 10ug/ml labeled vWF for cell binding (B). * denotes differences between vWF competition and control competition values (p < 0.05).
