Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Transl Stroke Res. 2011 Oct 20;3(1):138–145. doi: 10.1007/s12975-011-0112-2

Figure 4.

Figure 4

vWF rapidly activates immediate early genes in smooth muscle cells. A7R5 cells were pulsed with either vWF (200ng/ml) or buffer. RNA encoding four immediate early genes was rapidly upregulated (A–B). TSP1 and c-myc were moderately upregulated at 15 minutes and significantly repressed at 60 and 120 minutes. (C) Transcription of a cloned c-Fos promoter fused to the genetic reporter luciferase was also significantly acutely upregulated. * denotes differences compared to buffer control (p < 0.05).