Table 1.
Demographics and laboratory data of patients vaccinated against 2009 pandemic influenza virus
| Non-Seroprotected Vaccinated Renal Patients (n = 85) |
Non-Seroprotected Vaccinated Transplant Patients (n = 55) |
Non-Seroprotected Vaccinated Hemodialysis Patients (n = 30) |
||||
|---|---|---|---|---|---|---|
| SCV (n = 33) | Non-SCV (n = 52) | SCV (n = 23) | Non-SCV (n = 32) | SCV (n = 10) | Non-SCV (n = 20) | |
| Age (years) | 54.67 ± 15.08 | 63 ± 15.9 | 54.22 ± 12.35 | 57.59 ± 15.36 | 55.7 ± 20.84 | 71.65 ± 10.09 |
| Gender (male/female) | 20/13 | 34/18 | 12/11 | 21/11 | 8/2 | 13/7 |
| Weight (kg) | 70.04 ± 14.21 | 71.23 ± 14.56 | 72.52 ± 12.85 | 74.83 ± 15.42 | ||
| Seasonal vaccine (yes/no) | 25/8 | 9/43 | 17/6 | 27/5 | 8/2 | 16/4 |
| Time after transplant (months) | 62.12 (12.97; 159.37) | 31.34 (8.93; 60.197) | ||||
| Creatinine pre vaccine (mg/dl) | 1.95 ± 0.62 | 1.85 ± 0.53 | ||||
| MDRD-GFR pre vaccine (ml/min/1.73 m2) | 43.55 ± 19.15 | 44.19 ± 14.70 | ||||
| Serum proteins (g/L) | 7.4 (7.12; 8) | 7.4 (7.1; 7.8) | 7.4 (7.2; 8) | 7.4 (7.1; 7.67) | 7.5 (6.35; 8.15) | 7.6 (6.4; 8.2) |
| Serum albumin (g/L) | 4.24 ± 0.36 | 4.21 ± 0.63 | 4.33 ± 0.27 | 4.36 ± 0,40 | 4.03 ± 0.47 | 3.92 ± 0.88 |
| Proteinuria pre vaccine (mg/day) | 186 (106; 514) | 159 (117; 235) | ||||
| Hemoglobin (g/dl) | 12.8 (11.45; 14.05) | 13.1 (12.1; 13.8) | 12.9 (11.5; 14.1) | 13.5 (12.32; 13.9) | 12.55 (10.2; 14) | 12.4 (11.1; 13.5) |
| Leukocytes 103/mm3 | 7.521 ± 2.798 | 7.328 ± 2.331 | 8.235 ± 3.011 | 7.618 ± 2.408 | 5.880 ± 1.179 | 6.839 ± 2.170 |
| Ferritine (mg/dl) | 238 (59.5; 341.5) | 255 (136; 470) | 149 (39; 264) | 211 (47; 321) | 272.5 (119; 366.25) | 320.5 (194.5; 503.5) |
| PTH (pg/ml) | 152.5 (66.75; 203) | 112 (62.75; 207.25) | 125 (66.75; 191.5) | 83 (59; 138) | 172 (82; 497) | 200 (107; 391) |
| Creatinine post vaccine (mg/dl) | 2.00 ± 1.15 | 1.75 ± 0.76 | ||||
| Proteinuria post vaccine (mg/day) | 158 (124.5; 727.75) | 192 (122; 270) | ||||
| Steroid treatment (yes/no) | 14/9 | 20/12 | ||||
| Tacrolimus treatment (yes/no) | 20/2 | 28/4 | ||||
| Tacrolimus dose (mg/day) | 4.45 ± 2.86 | 4.16 ± 2.38 | ||||
| Tacrolimus trough levels (ng/ml) | 9.23 ± 2.41 | 9.12 ± 2.59 | ||||
| Treatment with MPA (yes/no) | 16/6 | 27/5 | ||||
| MPA trough levels (mcg/ml) | 1.85 (1.7; 2.35) | 2.15 (1.6; 2.67) | ||||
| Kt/V single pool (dose of dialysis) | 1.63 ± 0.32 | 1.81 ± 0.29 | ||||
| Time on dialysis (months) | 25.35 ± 23.13 | 43.98 ± 42.3 | ||||
All data are pre vaccine, except for those marked as post vaccine. Normal variables are expressed as mean ± standard deviation; not normal variables are expressed as median (75th percentile; 25th percentile range). SCV, seroconversion; MDRD GFR, modification of diet in renal disease study equation for estimating glomerular filtration rate; PTH, parathyroid hormone; MPA, mycophenolate.