Cumulative incidence of rapid estimated GFR (eGFR) loss (■, 346 cases, 1705 at risk) and of the combined end point of rapid GFR loss, incident ESRD, or death (, 559 cases, 2323 participants at risk) in the Cardiovascular Health Study, by serum 25-hydroxyvitamin D concentration. Adjusted for age, gender, race, site, season, attained education, household income, diabetes, smoking, physical activity, antihypertensive medication use, angiotensin-converting enzyme inhibitor use, body mass index, systolic and diastolic BP, and C-reactive protein.