Table 5.
Multivariate regression analysis between changes in soluble CD14 and other variables
| Model number | Beta | 95% CI Beta | P value |
|---|---|---|---|
| Model 1 | |||
| Change in parathyroid hormone | 0.38 | 0.11, 0.75 | 0.005 |
| Change in calcium | 0.35 | 0.09, 0.70 | 0.006 |
| Age | −0.19 | −0.59, 0.16 | 0.11 |
| Change in phosphate | 0.15 | −0.19, 0.32 | 0.21 |
| Independent variables: age, gender, dialysis vintage, and changes in serum calcium, phosphate, calcium-phosphate product and parathyroid hormone. | |||
| Model 2 | |||
| Change in interleukin-6 | 0.78 | 0.48, 0.96 | 0.004 |
| Change in interleukin-18 | 0.13 | −0.03, 0.31 | 0.08 |
| Dialysis vintage | 0.08 | −0.16, 0.20 | 0.28 |
| Independent variables: age, gender, dialysis vintage, and changes in serum hsPCR and cytokines. | |||
| Model 3 | |||
| Change in interleukin-6 | 0.76 | 0.40, 0.94 | 0.004 |
| Change in interleukin-18 | 0.13 | −0.04, 0.32 | 0.08 |
| Dialysis vintage | 0.08 | −0.015, 0.20 | 0.30 |
| Independent variables: Similar to Model 2 + changes in parathyroid hormone and calcium. | |||
| Model 4 | |||
| Change in interleukin-6 | 0.60 | 0.28, 0.89 | <0.0001 |
| Change in serum endotoxin | 0.31 | 0.18, 0.66 | <0.001 |
| Change in interleukin-10 | −0.13 | −0.38, 0.09 | 0.09 |
| Independent variables: Similar to Model 3 + changes in serum endotoxin concentrations. | |||
CI, confidence interval; hsCRP, high-sensitivity C-reactive protein.