Table 1.

Synthetic small molecules that function as potent inhibitors of the lectin DC-SIGN. Values are reported as the concentration required to inhibit 50% (IC₅₀) of the binding of a fluorescein mannosylated glycoconjugate to immobilized tetrameric DC-SIGN.⁶²

Compound	R1	R2	R3	IC50 (μM)
8	Pr	Et	Et	370 ± 70.0
9	Et	Me	Et	360 ± 69.2
10	Me	Me	Me	329 ± 65.8
11	Me	H	Me	313 ± 47.7
12	Boc	Et	Me	270 ± 43.8
13		Bn		170 ± 28.5
14		H		113 ± 20.4
15		H		71 ± 11
16		Et		68 ± 11
17		Bn		39 ± 6.2
18		H		23 ± 3.4
19		H		10 ± 1.3
20		H		4.4 ± 0.64
21		H		2.6 ± 0.28
22		H		0.31 ± 0.13