Table 1. General characteristic of studies included in the review.
Study | Year | Sample size Case/control | Institution | Subjects origin | Phenotype of cases | Mean age | Male% | Genotyping Method |
Lau[16] | 2006 | 163/232 | National Yang-Ming University, Taipei | Taiwan | Neovascular AMD | 76.1 | 81.8 | PCR-RFLP |
Chu[17] | 2008 | 144/126 | Peking Union Medical College Hospital | Beijing | Neovascular AMD | 67.2 | 54.8 | PCR-RFLP |
Lin[19] | 2008 | 133/180 | China Medical University Hospital | Taichung, Taiwan | Early AMD | NA | NA | Real-time PCR-based (melting curve analysis) |
Ng[20] | 2008 | 163/155 | Chinese University of Hong Kong | Hong Kong | Neovascular AMD | 74.3 | 50.3 | Direct sequencing |
Xu[21] | 2008 | 121/132 | Beijing Tongren Hospital | Beijing | Neovascular AMD | 66.1 | 54.9 | PCR-RFLP |
Pei[22] | 2009 | 123/130 | Peking University People's Hospital | Beijing | Neovascular AMD | 69.9 | 53.0 | Direct sequencing |
Gao[23] | 2010 | 208/140 | Beijing Tongren Hospital | Beijing | Soft drusen | 57.5 | 44.8 | PCR-RFLP |
Liu[24] | 2010 | 158/220 | Sichuan Provincial People's Hospital | Sichuan | Mixed (neovascular/soft drusen) | 64.2 | 54.6 | Direct sequencing |
80/220 | ||||||||
Yang[25] | 2010 | 109/150 | Affiliated Hospital of Nantong University | Nantong | Neovascular AMD | 64.8 | 46.7 | PCR-RFLP |
Dong[26] | 2011 | 136/140 | Qilu Hospital of Shandong University | Shandong | Neovascular AMD | 70.4 | 59.0 | PCR-RFLP |
AMD= age-related macular degeneration; PCR= polymerase chain reaction; RFLP=restriction fragment length polymorphism. NA =not available.