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Evaluation of halofuginone derivatives. Halofuginone (1 μM) inhibits P. berghei sporozoite load in HepG2 cells but N-acylated halofuginone derivatives (1 μM) are inactive. P. berghei parasite load in HepG2 cells was assessed by the relative luminescence signal 45 hours post-infection with a transgenic luciferase parasite reporter strain. Luminescence values were normalized to the DMSO control and reported as the average percent parasite load ± the standard deviation.
