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. 2012 Feb 2;7:4. doi: 10.1186/1750-1326-7-4

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Copyright ©2012 Heng et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Loss of TH⁺neurons and fibers in the VM of Top IIβ null mice. TH-immunostaining was performed in sagittal sections of E18.5 Top IIβ^+/+and Top IIβ^-/-mice brains. The location of TH⁺neurons areas were indicated by horizontal arrows (SNc) and arrowheads (VTA). Vertical arrowheads indicated the location of the TH⁺fibers extended from SNc and VTA (a and b). c and d showed in higher magnification that the TH⁺neurons in SNc was loss in Top IIβ^-/-mice, while the number also decreased in VTA. Bar = 100 μm.