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Cancer subtype classification based on nuclear layout patterns. (a) adenocarcinoma tissue image with snake-like glandular structure, (b) squamous carcinoma tissue image with sheet-like structure, (c,d) extract nuclei architecture, (e,f) scene abstraction to remove isolated or small islands of nuclei, (g,h) detect connecting components and look for large regions of connecting components as glandular structure for pattern recognition of adenocarcinoma.
