Table 5.
Variations within genes related to cell division, DNA replication and repair, transposition and phage integration
| Gene locus in NRRL 2338 | Length (amino acids) | Gene (locus) | Variationa | Protein function and notes |
|---|---|---|---|---|
| DNA replication and repair | ||||
| SACE_0826 | 1195 | mfd | Frameshift (+A 218/219) | Transcription/repair coupling factor |
| SACE_1351 | 269 | mutM, fpg | Missense (M199T) | Formamidopyrimidine DNA glycosylase |
| SACE_3677 | 147 | ogtl | Missense (G41K) | Methylated DNA-protein cysteine methyltransferase |
| SACE_4427 | 183 | Frameshift (+G 353/354) | G/U mismatch-specific DNA glycosidase | |
| SACE_5437 | 895 | polA | Frameshift (-C617) | DNA polymerase I |
| SACE_5255 | 207 | alkA | Missense (P68F) | 3-methyladenine DNA glycosylase |
| SACE_6108 | 693 | uvrD2 | IPM | ATP-dependent DNA helicase UvrD-like |
| Missense and in | ||||
| SACE_6681 | 873 | uvrD | frame deletion (G54-, G56R, S57I) | ATP-dependent DNA helicase UvrD |
| Cell division | ||||
| SACE_0667 | 941 | Missense (F874L) | DNA segregation ATPase FtsK/SpoIIIE | |
| SACE_6104 | 263 | IPM | Cell division initiation protein | |
| SACE_6929 | 579 | Missense (P159R) | ATPase involved in chromosome partitioning | |
| Transposition and phage integration | ||||
| SACE_0657 | 106 | Excision | lS1647-like transposase | |
| SACE_2154 | 350 | IPM | Transposase, IS891/IS1136/IS1341 | |
| SACE_2214and similar CDSs | 365 | Insertion between SACE_4827 and SACE_4228 | SACE-2214: Transposase SACE_4827: Oxidoreductase SACE_4228: LacI family transcriptional regulator | |
| SACE_2313 and similar CDSs | 99 | Insertion between SACE_2371 and SACE_2372 | SACE_2313: IS4-like transposase SACE_2371: IS4-like transposase SACE_2372: IS 1647-like transposase | |
| SACE_2322 | 374 | Missense (VI391) | Phage-related integrase/Site-specific recombinase XerC | |
| SACE_3579 | 469 | tnp | Missense (R13S, A73S, T118A, V309A) | Transposase, 1S1XX5 |
| SACE_4072 | 469 | tnp | Missense (S178L, Q191R, S199A,H218R, N370T, G430S, T431V) | Transposase, ISlxx5 |
| SACE_5073 | 459 | Missense (N171K) | Transposase, IS3508i | |
| Missense and in frame insertion | ||||
| SACE_5268 | 395 | (S73T, A74P, H129N,-134T, -135V,L191V, I216V A296V, P388R, S396L) | Transposase inactivated by frameshift mutation) | |
| SACE_5430 | 232 | Missense (H15R, R193W) | Transposase, Tn5714 | |
aIPM, imperfect match