Table 1.
Characteristics of studies included in the meta-analysis
| Author | n | Regimen of magnesium administrationa | Control regimen (route) | Total dose Mg2+ (mmol) | Magnesium | Controls | POAF | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Age (years), (male, %) | n | Age (years), (male, %) | n | Magnesium (%) Controls (%) | ||||||
| Fanning et al.[23] | 99 | 168 mEq over the first 4 postoperative days | 5% dextrose solution (IV) | 84 mmol | 59 (43-75) | 49 (71.4) | 62 (42-79) | 50 (78) | 7/49 (14.3) | 14/50 (28) |
| Colquhoun et al.[24] | 130 | 50 mmol during the first 48 h after surgery | 5% dextrose solution (IV) | 50 mmol | 57.1 ± 8.4 | 66 (83.3) | 58.7 ± 7.9 | 64 (79.7) | 11/66 (16.7) | 15/64 (23.4) |
| Nurozler et al.[26] | 50 | 100 mEq on the first operative day and 25 mEq per day from second to fifth days | Placebo (IV) | 100 mmol | 56.3 ± 1.6 | 25 (92) | 53.6 ± 2.0 | 25 (92) | 1/25 (4) | 5/25 (20) |
| Treggiari-Venzi et al.[25] | 98 | 4 g per 24 h continuous infusion for 72 h starting within 1 h of arrival in the ICU | 0.9% NaCl solution (IV) | 48 mmol | 65 (46-81) | 47 (89.4) | 65 (37-88) | 51 (84.3) | 11/47 (23) | 14/51 (27) |
| Hazelrigg et al.[21] | 202 | 80 mg/kg (ideal body weight) before cardiopulmonary bypass (CPB), 8 mg/kg/h (ideal body weight) intravenous (IV) infusion continued for 48 h | 5% dextrose solution (IV) | NA | 62.1 ± 9.5 | 105 (74) | 63.7 ± 11.1 | 97 (68) | 32/105 (30.5) | 41/97 (42.3) |
| Najafi et al.[11] | 345 | 2 g after induction of anesthesia until the start of cardiopulmonary bypass (CPB) and 8 g after CABG until 24 h after surgery | Placebo (IV) | 40 mmol | 59.1 (9.1) | 166 (75.9) | 59.7 (9.9) | 179 (76.5) | 12/166 (7.2) | 22/179 (12.3) |
| Hamid et al.[22] | 104 | 2 g after intubation | 0.9% NaCl solution (IV) | 8 mmol | 58.3 ± 7.6 | 53 (98) | 56.3 ± 8.9 | 51 (86) | 2/53 (3.77) | 5/51 (9.8) |
aTo convert units of g and mEq to mmol, the following conversions were used; 1 g = 4 mmol = 8 mEq for MgSO4.
CABG, coronary artery bypass grafting; CPB, cardiopulmonary bypass; ICU, intensive care unit;IV, intravenous; n, number of participants; NA, data not available; POAF, postoperative atrial fibrillation;