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. 2012 Apr 3;13:24. doi: 10.1186/1471-2350-13-24

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Copyright ©2012 Olesen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of I_Ks-WT and I_Ks-G60D channel currents. Representative current traces for KCNE1-WT (A) and KCNE1-G60D (B) channel subunits co-expressed with K_V7.1 in X.laevis oocytes in a 1:1 molar ratio. Current step protocol is shown as inset. C: I/V relationship for I_Ks-WT (n = 21) and I_Ks-G60D (n = 23) as determined from peak currents (open and filled squares). D: Voltage-dependence of I_Ks-WT and I_Ks-G60D channel activation as determined from tail currents (open and filled circles). E: Activation rise time, determined as the time to 1/2 max following a depolarization to 0 mV or +20 mV.