Table 5.

Correlation between DNA methylation and transcription in the candidate genes

Tissue	Methylation Candidate	CpG ID	Gene Transcript	Transcript ID	Correlation1	P value
Blood	MSX1	cg14167596	APOE	ILMN_1740938	0.76	< 0.001
		cg11930592	ATP6AP1	ILMN_1697694	0.32	0.03
		cg15755084			0.32	0.03
		cg20891301a			-0.302	0.04
		cg26615830			0.32	0.03
		cg15696627			0.44	0.002
		cg03717979			0.51	< 0.001
		cg15755084	PRSS21	ILMN_2382964	-0.38	0.01
		cg15696627			-0.37	0.01
		cg20588069			-0.42	0.003
		cg06677140			-0.29	0.04
		cg09573795		ILMN_1774256	-0.34	0.02
		cg03199651			-0.30	0.04
		cg20588069			-0.36	0.01
		cg22609784			-0.31	0.03
		cg15696627	RCOR1	ILMN_1743421	-0.28	0.05
		cg03717979		ILMN_1743421	-0.29	0.04
		cg06677140		ILMN_1743421	-0.38	0.01
Placenta	CDK2	cg09106999	GRB10	ILMN_1667771	-0.323	0.03
		cg00129774		ILMN_1669617	0.51	< 0.001
		cg00129774		ILMN_2340919	0.46	0.001
		cg04108502			0.37	0.01
		cg09304040	PGRMC1	ILMN_1684771	-0.34	0.02
		cg09106999	RGS14	ILMN_1696828	-0.31	0.03
	EVPL	cg24697031	EVPL	ILMN_1727288	-0.30	0.04
	GRB10	cg20651681	CDK2	ILMN_1653443	-0.29	0.04
		cg15774495			-0.28	0.05
		cg06790324			-0.36	0.01
		cg06386517	GRB10	ILMN_1669617	0.34	0.02
		cg20651681			0.39	0.01
		cg06790324			0.29	0.04
		cg03104936			0.29	0.05
		cg03104936		ILMN_1652662	0.37	0.01
		cg06386517		ILMN_2340919	0.33	0.02
		cg20651681			0.34	0.02
		cg24183958			0.38	0.01
		cg06790324			0.39	0.01
		cg20651681	PGRMC1	ILMN_1684771	-0.30	0.04
		cg03104936			-0.29	0.05
		cg20651681	RGS14	ILMN_1696828	-0.34	0.02
	NAT8L	cg08211091	GRB10	ILMN_1669617	-0.31	0.03

¹ Pearson correlation coefficient

² MSX1 has five CpGs that are positively correlated with ATP6AP1, however, cg20891301, which is anomalously negatively correlated is located at the end of the CpG island

³ CDK2 has three CpGs that are positively correlated with GRB10, however, one CpG, cg09106999 is negatively correlated