Table 8.
Each of the two random permutation six-gene models that also had positive R2 in the Infinium data set (from Table 7) were combined with each random permutation seven-gene model that achieved an R2 higher than the L1 Infinium model (25 models) for a total of 50, 13 gene models
| Data Set | Genes in model | Adjusted R2 and stability when tested on Infinium Data | Genes in resulting model | Gene name |
|---|---|---|---|---|
|
GoldenGate gene model which achieved R2 = 0.48 (stability 44/48) on the Infinium Data |
BEST1 IMPDH2 |
0.87 (44/48) |
CTTN GMDS |
Cortactin GDP-mannose 4,6-dehydratase |
| OSBPL5 | IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | ||
| PAX3 | OSBPL5 | oxysterol binding protein-like 5 | ||
| PSMC3 | PAX3 | paired box 3 | ||
| SERPINF1 | PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | ||
|
Infinium gene model which achieved better R2 than our model |
CTTN | REG1B | regenerating islet-derived 1 beta | |
| GMDS | RUVBL1 | RuvB-like 1 (E. coli) | ||
| REG1B | SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | ||
| VPS52 | VPS52 | vacuolar protein sorting 52 homolog | ||
| RUVBL1 | ||||
| KIAA241 |
Only one of the 50 models achieved higher R2 than the L1 13 gene model. Genes in bold have suggested role in fetal or placental growth and development