Table 9.
Top ten genes whose transcript levels are correlated with methylation of CpG sites in MSX1, CDK2 and GRB10
| Tissue | Methylation Gene | CpG ID | Expression Gene | Transcript ID | Correlation1 | Gene Name |
|---|---|---|---|---|---|---|
| Blood | MSX1 | cg14167596 | APOE | ILMN_1740938 | 0.76 | Apolipoprotein E |
| cg14167596 | CGA | ILMN_1734176 | 0.70 | Glycoprotein Hormones, Alpha Polypeptide | ||
| cg03199651 | KRT6C | ILMN_1754576 | 0.69 | Keratin 6 C | ||
| cg14167596 | PAPPA | ILMN_1721770 | 0.67 | Protein Kinase C And Casein Kinase Substrate in Neurons 1 | ||
| cg14167596 | PSG4 | ILMN_1693397 | 0.67 | Pregnancy Specific Beta-1-Glycoprotein 4 | ||
| cg26615830 | DCN | ILMN_2347145 | 0.65 | Decorin | ||
| cg14167596 | PSG6 | ILMN_2309615 | 0.65 | Pregnancy Specific Beta-1-Glycoprotein 6 | ||
| cg14167596 | CSH1 | ILMN_1693617 | 0.65 | Chorionic somatomammotropin hormone 1 (placental lactogen) | ||
| cg14167596 | GH2 | ILMN_1659354 | 0.65 | Growth Hormone 2 | ||
| cg14167596 | ADAM12 | ILMN_1726266 | 0.65 | ADAM Metallopeptidase Domain 12 | ||
| Placenta | CDK2 | cg04108502 | CXCL11 | ILMN_2067890 | 0.74 | Chemokine (C-X-C Motif) Ligand 11 |
| cg04108502 | HLA-DPB1 | ILMN_1749070 | 0.70 | Major Histocompatibility Complex, Classii, DP Beta 1 | ||
| cg04108502 | CXCL9 | ILMN_1745356 | 0.68 | Chemokine (C-X-C Motif) Ligand 9 | ||
| cg04108502 | GBP4 | ILMN_1771385 | 0.68 | Guanylate Binding Protein 4 | ||
| cg04108502 | GBP5 | ILMN_2114568 | 0.67 | Guanylate Binding Protein 5 | ||
| cg04108502 | UBD | ILMN_1678841 | 0.66 | Ubiquitin D | ||
| cg04108502 | VCY | ILMN_1683872 | 0.66 | Variable charge, Y-linked | ||
| cg04108502 | HLA-DRB3 | ILMN_1717261 | 0.66 | Major Histocompatibility Complex, Class II, DR Beta 3 | ||
| cg04108502 | CD3D | ILMN_2261416 | 0.65 | CD3d molecule, delta (CD3-TCR complex) | ||
| cg04108502 | CETP | ILMN_1681882 | 0.65 | Cholesteryl ester transfer protein, plasma | ||
| GRB10 | cg20651681 | SHROOM2 | ILMN_1681777 | 0.68 | Shroom Family Member 2 | |
| cg20651681 | MESDC1 | ILMN_1781565 | 0.67 | Mesoderm Development Candidate 1 | ||
| cg20651681 | CCDC146 | ILMN_1790555 | 0.67 | Coiled-Coil Domain Containing 146 | ||
| cg20651681 | VANGL2 | ILMN_1715647 | 0.67 | Vang-Like2 (Vangogh, Drosophila) | ||
| cg06790324 | SCG2 | ILMN_1703178 | 0.66 | Secretogranin II | ||
| cg20651681 | STGC3 | ILMN_1807244 | 0.66 | hypothetical STGC3 | ||
| cg06790324 | ABHD14B | ILMN_2227533 | 0.66 | Ab Hydrolase Domain Containing 14B | ||
| cg20651681 | TLL1 | ILMN_1699814 | 0.66 | Tolloid-Like 1 | ||
| cg20651681 | SOD1 | ILMN_1662438 | -0.65 | Superoxide Dismutase 1, Soluble | ||
| cg06790324 | INPP5E | ILMN_1811301 | 0.65 | Inositol polyphosphate-5-phosphatase, 72 kDa |
Genes in bold have suggested role in fetal or placental growth and development
1 Pearson correlation coefficient (P ≤ 0.01)