Table 2.

Characteristics of predicted PfHRP2 kinetics in illustrative untreated infections

Patient	Day of first fever	PfHRP2 threshold (ng/mL)	Fitted model		Unadjusted model
			First day above threshold (MinCM, MaxCM)	Days above threshold (range)	First day above threshold (MinCM, MaxCM)	Days above threshold (range)
S561	2	100	2,2	32-34	4,3	9-15
		20	2,2	39-46	2,2	19-25
		10	2,2	44-51	2,2	24-31
S707	4	100	2,2	25-29	7,5	2-6
		20	2,2	31-35	5,5	10-15
		10	2,1	34-40	5,3	13-25
S811	2	100	2,2	50-56	4,4	2-7
		20	2,2	59-64	4,2	21-31
		10	2,2	63-68	2,2	29-47

The kinetics are summarized by the day they first exceed a nominated threshold under the minimum (MinCM) and maximum circulating PfHRP2 models (MaxCM) and the total number of days they are above this threshold. A range for the number of days above the threshold is given by combining the results from the MinCM and MaxCM models. Results are presented using the mean PfHRP2 production fitted in this study (fitted model) and also the previously reported PfHRP2 production of 5.2 fg/parasite/replication cycle (unadjusted model) [8].