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. 2012 May 23;7(5):e37757. doi: 10.1371/journal.pone.0037757

Figure 3. Effect of topiramate on hepatic biomarkers.

Figure 3

The panels illustrate the effect of topiramate (40 & 100 mg/kg, p.o; TPM40, TPM100) on hepatic (A, B) insulin receptor isoforms (high affinity, [HAIR, fmol/mg protein] and low affinity [LAIR, pmol/mg protein] insulin receptor), (C, D) adiponectin receptors (Adipo-R1, Adipo-R2 [ng/mg protein]), (E) protein tyrosine kinase (PTK [U/mg protein]), and (F) glucose transporter-2 (GLUT2 [mg/mg protein]) of obese/insulin resistant rats fed high fat and high fructose diet [HFFD] for 10 weeks (mean of 10 animals ± S.D.). Treatments were administered once daily for 2 weeks. As compared with normal control (*), HFFD (†) and HFFD+TPM40 (‡) groups (one-way ANOVA followed by Tukey–Kramer Test), P<0.05.