Table 1. Effect of topiramate on serum and tissue biomarkers of normal control rat.
| Normal Control (NFD+saline) | Normal Control +TPM40 | Normal Control +TPM100 | |
| Glucose (mg/dl) | 82±7.1 | 85±6 | 86±8 |
| Insulin (µIU/ml) | 14.5±3 | 16.2±3 | 16.8±4 |
| HOMA-index | 2.97±0.2 | 3±0.5 | 3.2±0.4 |
| Fructosamine (nmol/L) | 129.4±11.6 | 135.2±12 | 137.5±13 |
| AUC | 229±22 | 249±15 | 219±16 |
| TG (mg/dl) | 42±4 | 44±4 | 45±3 |
| TC (mg/dl) | 61±5.4 | 63±6 | 59±5 |
| FFAs (mmol/L) | 0.79±0.08 | 0.72±0.08 | 0.82±0.1 |
| ALT (IU/L) | 40±5 | 42±3 | 39±4 |
| TNF-α (pg/ml) | 11±1.5 | 12±1.6 | 10.5±0.9 |
| Adiponectin(ng/ml) | 1.4±0.2 | 1.5±0.3 | 1.6±0.5 |
| BW (g) | 250±20 | 240±13 | 232±20 |
| LW (g)/BWx100 | 2.5±0.15 | 2.4±0.2 | 2.4±0.3 |
| VFW (g)/BWx100 | 0.73±0.03 | 0.75±0.03 | 0.72±0.02 |
| EFW (g)/BWx100 | 0.35±0.04 | 0.37±0.03 | 0.3±0.02 |
Effect of 14 days administration of topiramate (40, 100 mg/kg) to normal control rats fed normal diet. The following markers were assessed: serum levels of glucose, insulin, and fructosamine, HOMA-index and area under the curve (AUC); serum triglycerides (TGs), total cholesterol (TC), free fatty acids (FFAs), ALT (IU/L), tumor necrosis alpha (TNF-α) and adiponectin; body weight (BW) and liver weight (LW)/−, visceral fat weight (VFW)/− and epididymal fat weight (EFW)/−BW ratio. Values are means (± S.D.) of 10 animals. Treatments were administered once daily for 2 weeks. Statistical analysis between groups was carried out using one-way ANOVA followed by Tukey-Kramer Test, P<0.05.