Table 2. Effect of topiramate on the indicators of glucose homeostasis of obese/insulin resistant rats.
| Glucose (mg/dl) | Insulin (µIU/ml) | HOMA-index | Fructosamine (nmol/L) | AUC | |
| Normal Control | 82±7.1 | 14.5±3 | 2.97±0.2 | 129.4±11.6 | 229±22 |
| HFFD | 165±13* | 35.1±2 * | 14.47±1.3* | 191.3±13.5 * | 546±43.0* |
| HFFD+TPM40 | 128±11*† | 17.8±2 † | 5.69±0.4*† | 135.4±12.5 † | 312±24*† |
| HFFD+TPM100 | 112±8*†‡ | 15.6±3 † | 4.36±0.3*†‡ | 136.8±14 † | 269±24.9† |
Effect of topiramate (40, 100 mg/kg; TPM40, TPM100) on serum levels of glucose, insulin, and fructosamine, HOMA-index and area under the curve of the GTT of obese/insulin resistant rats fed high fat and high fructose diet [HFFD] for 10 weeks. Values are means (± S.D.) of 10 animals. Treatments were administered once daily for 2 weeks. As compared with normal control (*), HFFD (†) and HFFD+TPM40 (‡) groups (one-way ANOVA followed by Tukey–Kramer Test), P<0.05.