Table 3. Effect of topiramate on body-, liver- and fat weights of obese/insulin resistant rats.
BW (g) | LW/BW x100 | VFW/BWx100 | EFW/BWx100 | |
Normal Control | 250±20 | 2.5±0.15 | 0.73±0.03 | 0.35±0.04 |
HFFD group | 348±35* | 3.18±1.27* | 1.01±0.09* | 0.78±0.08* |
HFFD+TPM40 | 347.5±37* | 2.90±0.2* | 0.85±0.1 | 0.68±0.07* |
HFFD+TPM100 | 325±40* | 2.69±0.2† | 0.78±0.04† | 0.56±0.06 † |
Effect of topiramate (40, 100 mg/kg; TPM40, TPM100) on body weight (BW) and liver weight (LW)/−, visceral fat weight (VFW)/− and epididymal fat weight (EFW)/−BW ratio of obese/insulin resistant rats fed high fat and high fructose diet [HFFD] for 10 weeks. Values are means (± S.D.) of 10 animals. Treatments were administered once daily for 2 weeks. As compared with normal control (*), and HFFD (†) groups (one-way ANOVA followed by Tukey-Kramer Test), P<0.05.