. 2012 May 23;7(5):e37757. doi: 10.1371/journal.pone.0037757

Table 3. Effect of topiramate on body-, liver- and fat weights of obese/insulin resistant rats.

	BW (g)	LW/BW x100	VFW/BWx100	EFW/BWx100
Normal Control	250±20	2.5±0.15	0.73±0.03	0.35±0.04
HFFD group	348±35^*	3.18±1.27^*	1.01±0.09^*	0.78±0.08^*
HFFD+TPM₄₀	347.5±37^*	2.90±0.2^*	0.85±0.1	0.68±0.07^*
HFFD+TPM₁₀₀	325±40^*	2.69±0.2^†	0.78±0.04^†	0.56±0.06 ^†

Effect of topiramate (40, 100 mg/kg; TPM₄₀, TPM₁₀₀) on body weight (BW) and liver weight (LW)/−, visceral fat weight (VFW)/− and epididymal fat weight (EFW)/−BW ratio of obese/insulin resistant rats fed high fat and high fructose diet [HFFD] for 10 weeks. Values are means (± S.D.) of 10 animals. Treatments were administered once daily for 2 weeks. As compared with normal control (^*), and HFFD (^†) groups (one-way ANOVA followed by Tukey-Kramer Test), P<0.05.