Table 2. Frequency (F) and number (n) of IgG responders and non-responders to the PvMSP-3α recombinant proteins tested by HLA-DRB1* and HLA-DQB1*allelic groups from malaria naturally exposed individuals.
| HLA | MSP3FL | MSP3BLI | MSP3BLII | MSP3CT | MSP3NT | |||||
| Responder | Non-responder | Responder | Non-responder | Responder | Non-responder | Responder | Non-responder | Responder | Non-responder | |
| f (n) | f (n) | f (n) | f (n) | f (n) | f (n) | f (n) | f (n) | f (n) | f (n) | |
| HLA-DRB1 * | ||||||||||
| DRB01 | 0.105 (45) | 0.089 (11) | 0.114 (39) | 0.081 (17) | 0.106 (31) | 0.096 (25) | 0.085 (25) | 0.120 (31) | 0.089 (19) | 0.109 (37) |
| DRB03 | 0.079 (34) | 0.073 (9) | 0.076 (26) | 0.081 (17) | 0.086 (25) | 0.069 (18) | 0.078 (23) | 0.078 (20) | 0.098 (21) | 0.065 (22) |
| DRB04 | 0.164 (70) | 0.169 (21) | 0.178 (61) | 0.143 (30) | 0.168 (49) | 0.162 (42) | 0.201 (59) | 0.124 (32) | 0.206 (44) | 0.139 (47) |
| DRB07 | 0.110 (47) | 0.105 (13) | 0.105 (36) | 0.114 (24) | 0.103 (30) | 0.115 (30) | 0.116 (34) | 0.101 (26) | 0.084 (18) | 0.124 (42) |
| DRB08 | 0.091 (39) | 0.073 (9) | 0.082 (28) | 0.095 (20) | 0.089 (26) | 0.085 (22) | 0.075 (22) | 0.101 (26) | 0.103 (22) | 0.077 (26) |
| DRB09 | 0.019 (8) | 0.0 (0) | 0.012 (4) | 0.019 (4) | 0.014 (4) | 0.015 (4) | 0.014 (4) | 0.016 (4) | 0.019 (4) | 0.012 (4) |
| DRB10 | 0.009 (4) | 0.016 (2) | 0.012 (4) | 0.010 (2) | 0.014 (4) | 0.080 (2) | 0.010 (3) | 0.012 (3) | 0.0 (0) | 0.018 (6) |
| DRB11 | 0.098 (42) | 0.065 (8) | 0.091 (31) | 0.090 (19) | 0.089 (26) | 0.092 (24) | 0.095 (28) | 0.085 (22) | 0.089 (19) | 0.092 (31) |
| DRB12 | 0.009 (4) | 0.0 (0) | 0.009 (3) | 0.003 (1) | 0.010 (3) | 0.004 (1) | 0.010 3) | 0.004 (1) | 0.014 (3) | 0.003 (1) |
| DRB13 | 0.103 (44) | 0.121 (15) | 0.114 (39) | 0.095 (20) | 0.103 (30) | 0.112 (29) | 0.102 (30) | 0.112 (29) | 0.098 (21) | 0.112 (38) |
| DRB14 | 0.072 (31) | 0.089 (11) | 0.067 (23) | 0.090 (19) | 0.075 (22) | 0.077 (20) | 0.085 (25) | 0.066 (17) | 0.056 (12) | 0.089 (30) |
| DRB15 | 0.077 (33) | 0.081 (10) | 0.076 (26) | 0.081 (17) | 0.082 (24) | 0.073 (19) | 0.061 (18) | 0.097 (25) | 0.079 (17) | 0.077 (26) |
| DRB16 | 0.063 (27) | 0.121 (15) | 0.064 (22) | 0.095 (20) | 0.062 (18) | 0.092 (24) | 0.068 (20) | 0.085 (22) | 0.065 (14) | 0.083 (28) |
| HLA-DQB1 * | ||||||||||
| DQB02 | 0.153 (66) | 0.137 (17) | 0.145 (50) | 0.157 (33) | 0.140 (41) | 0.160 (42) | 0.156 (46) | 0.142 (37) | 0.140 (30) | 0.156 (53) |
| DQB03 | 0.384 (165) | 0.379 (47) | 0.384 (132) | 0.381 (80) | 0.370 (108) | 0.397 (104) | 0.435 (128) | 0.323 (84) | 0.416 (89) | 0.362 (123) |
| DQB04 | 0.112 (48) | 0.105 (13) | 0.305 (36) | 0.119 (25) | 0.116 (34) | 0.103 (27) | 0.099 (29) | 0.123 (32) | 0.117 (25) | 0.106 (36) |
| DQB05 | 0.172 (74) | 0.185 (23) | 0.186 (64) | 0.157 (33) | 0.185 (54) | 0.164 (43) | 0.163 (48) | 0.188 (49) | 0.145 (31) | 0.194 (66) |
| DQB06 | 0.179 (75) | 0.194 (24) | 0.180 (60) | 0.186 (39) | 0.188 (53) | 0.176 (46) | 0.146 (41) | 0.223 (58) | 0.182 (37) | 0.182 (62) |
Bold typeface indicates the frequency of IgG responses were associated to the particular HLA-DRB1* or HLA-DQB1* allelic group by the bipartition χ2 test (P<0.05).
Each studied individual contributed two HLA allele observations to this descriptive analysis.