Table 1. Demographics.

	Controls	Clinically Isolated Syndrome	Relapsing-Remitting MS	Secondary Progressive MS	Primary Progressive MS
	(N = 53)	(N = 45)	(N = 403)	(N = 60)	(N = 33)
Age Mean (SD)	34.6 (11.1)	39.3 (10.2)**	42.3 (11.1)**	51.4 (10.7)**	52 (11.8)**
Sex (% Female)	57	80**	72*	68	45
Disease Duration Median (IQR) in years	–	1 (0.3–2.5)	6.7 (2.7–12.1)	13.5 (6.4–21.2)	8.6 (4–11.7)
Expanded Disability Status Scale (EDSS) Median (IQR)	–	1.5 (1–2)	2 (1.5–3.5)	5.5 (4–6.5)	5.5 (4–6.5)

^* p<0.05;

^** p<0.01 – Statistical differences refer to comparison with unaffected controls.