Table 6. CVD risk factors in 1994–1995 and serum PTH in 2001–2002 in relation to genotype score quartile and genotypes in the four selected SNPs in the entire study cohort of 9471 subjects.

SNP and genotypes		Systolic blood pressure (mmHg)	BMI (kg/m2)	Total cholesterol (mmol/L)	Tri-glycerides (mmol/L)	HbA1c (%)**	Serum PTH (pmol/L)***
Genotype score	Quartile 1****	145.5±24.3	26.0±4.2	6.56±1.33	1.70±1.11	5.55±0.83	3.64±1.97
	Quartile 2	144.9±23.6	26.1±4.2	6.59±1.32	1.70±1.01	5.53±0.67	3.71±1.95
	Quartile 3	145.0±23.7	25.9±4.3	6.63±1.33	1.68±1.10	5.53±0.71	3.68±1.74
	Quartile 4	144.9±23.7	25.9±4.1	6.58±1.31	1.72±1.15	5.53±0.69	3.78±1.91
rs2298850	Major homozygote	145.3±24.0	26.0±4.2	6.58±1.33	1.70±1.08	5.55±0.75	3.73±1.99
	Heterozygote	144.6±23.6	25.9±4.1	6.60±1.32	1.68±1.09	5.51±0.69	3.65±1.72
	Minor homozygote†	146.0±23.9	25.9±3.9	6.57±1.32	1.75±1.17	5.51±0.63	3.67±1.87
rs10741657	Major homozygote†	144.3±23.3	25.9±4.1	6.57±1.34	1.70±1.12	5.53±0.68	3.76±1.96
	Heterozygote	145.7±23.9	26.1±4.2	6.60±1.31	1.71±1.09	5.53±0.73	3.66±1.83
	Minor homozygote	144.9±24.5	25.9±4.2	6.58±1.32	1.65±1.02	5.54±0.79	3.69±1.93
rs3794060	Major homozygote	144.7±23.8	26.0±4.2	6.56±1.32	1.67±1.06	5.56±0.83	3.63±1.76
	Heterozygote	144.9±23.5	26.0±4.1	6.59±1.32	1.72±1.11	5.52±0.67	3.74±2.00
	Minor homozygote†	146.5±24.8	26.0±4.2	6.62±1.33	1.71±1.12	5.52±0.60	3.79±1.88
rs6013897	Major homozygote	145.0±24.0	25.9±4.1	6.60±1.31	1.72±1.10	5.52±0.71	3.56±1.87*
	Heterozygote	145.2±23.5	26.0±4.2	6.57±1.34	1.67±1.09	5.54±0.75	3.88±1.96
	Minor homozygote†	145.2±23.7	26.1±4.3	6.59±1.27	1.73±1.04	5.57±0.71	3.98±1.79

^*P<0.05 for linear trend across genotype, linear regression with gender, age, BMI, vitamin D/cod liver oil supplementation and season as covariates. Correction for multiple comparisons for the individual SNPs was performed with a factor of 5.

^**Analyzed in 4613 subjects;

^***Analyzed in 3809 subjects in the fifth survey in 2001–2002.

^****Quartile with highest serum 25(OH)D level.

^†Risk allele.