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. 2012 May 23;7(5):e37955. doi: 10.1371/journal.pone.0037955

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Jacobs et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Lewis rats were implanted with 3×10⁵ CNS-1 cells. Tumors were collected on day 10 from tumor bearing rats and untreated rats, and then stained for microglia (CD45^+lo, CDllb⁺), macrophages (CD45^+hi, CDllb⁺) and TROY. Gating is shown in figure, histogram is representative of 6 rats/group. (B) Lewis rats were implanted with CNS-1 cells and then treated with 50 mg/kg PPF or saline on day 8 for 2 days. Tumors were collected and stained for microglia (CD45^+lo, CDllb⁺), macrophages (CD45^+hi, CDllb⁺) and TROY. Histogram is representative of 3 rats/group.