Table 2. Validation of mutations in previously collected archival FFPE samples from the ONB patient.

Sample Date	Site examined	MYC	KDR	TAOK2	MAP4K2	SIN3B	TP53	NLRC4	Comments
6/2/08	Left nasal mass	CCC	AGG	GAC	ATC	AAG	TTC	AGG	At diagnosis, mutations in TAOK2/MAP4K2/TP53
	Right nasal mass	CCC	AGG	GAC	ATC	AAG	TTC	AGG
6/12/08	Frontal tumor	CCC	AGG	GAC	ATC	AAG	TTC	AGG	Resection samples do not have new mutations
	Nasal tumor	CCC	N/A	GAC	ATC	AAG	TTC	AGG
7/26/10	Right cheek	CTC	AAG	GAC	ATC	ATG	TTC	AAG	Metastatic samples show evolution of new mutations in MYC/KDR/SIN3B/NLRC4
	Right cheek	CTC	AAG	GAC	ATC	ATG	TTC	AAG
11/3/10	Right cheek (WGS)	CTC	AAG	GAC	ATC	ATG	TTC	AAG
		CCC	AGG	GGC	AGC	AAG	TGC	AGG	Reference codons

Key: Validated mutations compared to reference codon depicted in bold italics.