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Age- and training-associated differences in pCREB and CREB immunoreactivity in area CA3 of the hippocampus. (A) Representative photomicrographs of pCREB immunostaining. Scale bar = 50 µm. (B) pCREB levels were similar between young and old rats and not significantly altered by training. (C) There were significantly lower CREB levels in old compared to young rats. (D) There were no significant age- or training-related differences in pCREB:CREB ratios.
