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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Mech Ageing Dev. 2012 Mar 16;133(5):291–299. doi: 10.1016/j.mad.2012.03.004

Figure 5.

Figure 5

Age- and training-associated differences in pCREB and CREB immunoreactivity in the basolateral amygdala. (A) Representative photomicrographs of pCREB immunostaining. Scale bar = 50 µm. (B) Young rats had significantly enhanced pCREB levels following training with a low or moderate intensity foot shock, whereas old rats had training-related deficits in pCREB activation. (*) p < .05 vs. young cage controls. (**) ps < .01 vs. young cage controls and no shock. (C) Total CREB levels were significantly lower in old compared to young rats. (D) Young rats had significantly higher ratios of pCREB:CREB after training with a low or moderate intensity foot shock, whereas old rats had training-related deficits in pCREB:CREB ratios. (*) p < .05 vs. young cage controls. (**) ps < .05 vs. young cage controls and no shock.