Table 3.
P5 | P15 | P30 | ||
---|---|---|---|---|
Subcellular Compartment | Extrasynaptic density (immunoparticles/μm2) |
Extrasynaptic density (immunoparticles/μm2) |
Extrasynaptic density (immunoparticles/μm2) |
Synaptic density (immunoparticles/μm2) |
Spines (SLM) | 0.3 ± 0.1 | 2.9 ± 0.3 | 9.5 ± 0.6 | 1.9 ± 0.1^ |
Spines (SR, distal) | 0.6 ± 0.1 | 3.0 ± 0.2 | 5.3 ± 0.4***# | 1.7 ± 0.1^ |
Spines (SR, proximal) | 0.4 | 2.7 ± 0.1 | 2.8 ± 0.5*** | 1.4 ± 0.1^ |
Somata | 0.5 | 0.6 ± 0.1* | 0.3** | 0 |
P <0.001 for somata compared to spines
P <0.001 for somata compared to spines
P <0.001 for proximal and distal SR compared to SLM
P <0.001 for proximal SR compared to distal SR
P <0.05 each subfield