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. Author manuscript; available in PMC: 2013 Jun 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Apr 13;261(3):227–235. doi: 10.1016/j.taap.2012.04.009

Figure 2. Effect of CHO (mEH inhibitor) on DMBA- or DMBA-3,4-diol-induced follicle loss.

Figure 2

Ovaries from PND4 Fischer 344 rats were cultured with (A) vehicle control or media containing DMBA (1 μM) ± CHO (2 mM) for 4 d; or (B) vehicle control or media containing DMBA-3,4-diol (75 nM) ± CHO (2 mM) for 4 d. Following incubation, ovaries were collected, processed for histological evaluation and healthy follicles were counted. Values are mean ± SE total follicles counted/ovary, n=5. Different letters indicate significant difference between follicle number (Adapted from Igawa et al., 2009 with copyright permission).