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On microscopic view, GIST either show spindle cell [a hematoxylin–stain (HE)] or epithelioid differentiation (b), HE, the latter of which being most frequent in gastric GIST. Immunostaining with CD117 (KIT) is characteristically positive in GIST of either differentiation (c spindle cell, d epithelioid). Immunostaining with PDGFRA is typically weaker in spindle cell GIST (e) than in epithelioid GIST (f) (×100)
