Fig. 2.

Brain activities induced by deep somatosensory stimulation (blue) and transcranial magnetic stimulation to the primary motor cortex (red) in healthy volunteers. The overlap of the two is shown in green. The overlapping activity partially corresponds to the pain matrix, which is composed of the cingulate cortex, the insula/parietal operculum including the second somatosensory cortex, and the thalamus. Overlap is also observed in nonpain matrix areas, such as the primary motor cortex, the primary somatosensory cortex, the supplementary motor cortex, and the basal ganglia. The figure shows a new illustration based on data from Shitara et al. [20]