Table 1.

Brain regions possibly involved in the pathogenesis of deafferentation pain

Regions	Reorganization	Pain matrix	Somatosensory stimulation	M1 stimulation
Primary motor cortex (M1)	++	+ (Nonthermal)	+	+
Primary somatosensory cortex (S1)	++	+ (Nonthermal)	++	++
Supplementary motor/premotor areas	?	+ (Nonthermal)	++	++
Cingulate cortex	?	++	++	++
Insula-parietal operculum (S2)	?	++	++	++
Thalamus	+	++	++	++
Basal ganglia	?	−	+	++

++ frequently reported, + occasionally reported, ? not clear