Table 3.
Univariate analysis of the risk factors for anastomotic leakage
| Variable | Total cohort (n = 285) | Cases with leakage (n = 15) | Cases without leakage (n = 270) | P value |
|---|---|---|---|---|
| Surgery | ||||
| Elective | 263 (92.3%) | 14 (93.3%) | 249 (92.2%) | >0.999 |
| Acute | 22 (7.7%) | 1 (6.7%) | 21 (7.8%) | >0.999 |
| Laparotomy | 182 (63.9%) | 10 (66.7%) | 172 (63.7%) | >0.999 |
| Laparoscopy | 103 (36.1%) | 5 (33.3%) | 98 (36.3%) | >0.999 |
| Of which conversion | 28 (27.2%) | 2 (40%) | 26 (26.5%) | 0.649 |
| Anastomosis, right | 84 (29.5%) | 0 | 84 (31.1%) | >0.999 |
| Anastomosis, left | 161 (56.5%) | 15 (100%) | 146 (4.1%) | <0.001 |
| Other | 40 (14.0%) | 0 | 40 (14.8%) | >0.999 |
| Duration of surgery (min) | 241 ± 82 | 252 ± 67 | 240 ± 82 | 0.306 |
| Intraoperative adverse eventa | 17 (6.0%) | 3 (20%) | 14 (5.2%) | 0.050 |
| Total intraoperative fluid intake (mL) | 3513 ± 1315 | 3523 ± 1040 | 3513 ± 1331 | 0.915 |
| Blood loss (mL) | 387 ± 437 | 423 ± 296 | 384 ± 446 | 0.015 |
| Blood loss ≥250 mL | 87 (30.5%) | 10 (66.7%) | 77 (28.5%) | 0.003 |
| Neuraxial technique | 250 (87.7%) | 13 (86.7%) | 237 (87.8%) | 0.390 |
| Preoperative DBP (mmHg) | 81 ± 12 | 87 ± 10 | 81 ± 13 | 0.019 |
| DBP ≥90 mmHg | 79 (27.7%) | 9 (60%) | 70 (25.9%) | 0.008 |
| Preoperative SBP (mmHg) | 141 ± 20 | 136 ± 17 | 142 ± 20 | 0.398 |
| SBP ≥150 mmHg | 92 (32.3%) | 4 (26.7%) | 88 (32.6%) | 0.780 |
| DBP: intraoperative ↓ >25% (yes or no) | 267 (93.7%) | 15 (100%) | 252 (93.3%) | >0.999 |
| Duration (min), mean ± SD | 112 ± 84 | 137 ± 92 | 111 ± 84 | 0.278 |
| Intraoperative ↓ DBP >40% (yes or no) | 209 (73.3%) | 14 (93.3%) | 195 (72.2%) | 0.127 |
| Duration (min), mean ± SD | 38 ± 57 | 51 ± 57 | 37 ± 57 | 0.049 |
| SBP: intraoperative ↓ >25% (yes or no) | 263 (92.3%) | 15 (100%) | 248 (91.9%) | >0.999 |
| Duration (min), mean ± SD | 93 ± 71 | 86 ± 58 | 93 ± 72 | 0.862 |
| Intraoperative ↓ SBP >40% (yes or no) | 205 (71.9%) | 13 (86.7%) | 192 (71.1%) | 0.368 |
| Duration (min), mean ± SD | 27 ± 43 | 22 ± 34 | 28 ± 43 | 0.923 |
| Intraoperative use of vasoactive drugs | 213 (74.7%) | 12 (80%) | 201 (74.4%) | 0.768 |
aIntraoperative adverse events reported: lesion spleen, ureter, bladder or ileum, torsion of the anastomosis, acute massive bleeding, positive air bubble test