Table 5.
Details and results for qPCR analyses
| Location | Alteration detected | ||||
|---|---|---|---|---|---|
| Gene locus | Mb | Cytoband | Type | LPTA cases 1–21 | Adenomas (n=58) |
| Chromosome 1 | |||||
| RNF11 | 51.7 | 1p32.3 | Loss | 7/21 cases (33%) | ND |
| Chromosome 5 | |||||
| TERT | 1.2 | 5p15.33 | Gain | 5/21 cases (24%) | ND |
| CARD6 | 40.8 | 5p13.1 | Gain | 4/21 cases (19%) | 0/58 cases (0%) |
| PIK3R1 | 67.5 | 5q13.1 | Gain | 11/21 cases (52%) | 2/58 cases (3%) |
| APC | 112.0 | 5q22.2 | Gain | 6/21 cases (29%) | 2/58 cases (3%) |
| LMNB1 | 126.1 | 5q23.2 | Gain | 4/21 cases (19%) | 0/58 cases (0%) |
| Chromosome 11 | |||||
| MEN1 | 64.6 | 11q13.1 | Loss | 6/21 cases (29%) | ND |
| Reference gene | |||||
| RNaseP | 19.9 | 14q11.2 | |||
Reported alterations were observed by one or both assays used for each gene. ND, not determined.