Table 1.
Cohort | n | Peginesatide Starting Dose | Dosing Frequency | Route of Administration |
---|---|---|---|---|
A | 45 | 0.05 mg/kg | Q4W | SC |
B | 15 | 0.075 mg/kg | Q4W | SC |
C | 15 | 0.025 mg/kg | Q4W | SC |
D | 15 | 0.05 mg/kg | Q4W | IV |
E | 15 | 0.025 mg/kg | Q2W | SCa |
F | 4 | 0.0375 mg/kg | Q2W | SC |
G | 15 | 4.0 mg | Q4W | SC |
H | 15 | 3.0 mg | Q4W | SC |
Q4W, every 4 weeks; SC, subcutaneous; IV, intravenous; Q2W, every 2 weeks.
Because of dosing errors, two patients received their peginesatide doses via the intravenous route rather than the subcutaneous route.