Table 2.
Demographic and baseline characteristics
| Characteristic | Cohort A (0.05 mg/kg SC Q4W n = 45) | Cohort B (0.075 mg/kg SC Q4W n = 15) | Cohort C (0.025 mg/kg SC Q4W n = 15) | Cohort D (0.05 mg/kg IV Q4W n = 15) | Cohort E (0.025 mg/kg SC Q2W n = 15) | Cohort F (0.0375 mg/kg SC Q2W n = 4) | Cohort G (4.0 mg SC Q4W n = 15) | Cohort H (3.0 mg SC Q4W n = 15) | Total (n = 139) |
|---|---|---|---|---|---|---|---|---|---|
| Age, mean (SD), years | 64.8 (13.6) | 64.7 (14.3) | 63.9 (12.3) | 59.9 (16.0) | 62.5 (14.6) | 68.3 (12.6) | 68.7 (13.0) | 65.7 (15.0) | 64.5 (13.8) |
| Men, n (%) | 26 (57.8) | 11 (73.3) | 8 (53.3) | 5 (33.3) | 6 (40.0) | 0 | 12 (80.0) | 7 (46.7) | 75 (54.0) |
| Race, n (%) | |||||||||
| white | 32 (71.1) | 7 (46.7) | 10 (66.7) | 10 (66.7) | 13 (86.7) | 4 (100.0) | 11 (73.3) | 14 (93.3) | 101 (72.7) |
| black | 7 (15.6) | 3 (20.0) | 2 (13.3) | 1 (6.7) | 1 (6.7) | 0 | 1 (6.7) | 0 | 15 (10.8) |
| other | 6 (13.3) | 5 (33.3) | 3 (20.0) | 4 (26.7) | 1 (6.7) | 0 | 3 (20.0) | 1 (6.7) | 23 (16.5) |
| Weight, mean (SD), kg | 77.9 (16.3) | 81.3 (13.8) | 84.7 (26.0) | 71.5 (17.4) | 81.4 (23.9) | 67.3 (21.0) | 82.0 (19.7) | 76.2 (16.7) | 78.6 (18.8) |
| Primary cause of CKD, n (%) | |||||||||
| diabetes | 14 (31.1) | 7 (46.7) | 8 (53.3) | 6 (40.0) | 6 (40.0) | 1 (25.0) | 8 (53.3) | 5 (33.3) | 55 (39.6) |
| hypertension | 7 (15.6) | 0 | 1 (6.7) | 0 | 2 (13.3) | 1 (25.0) | 1 (6.7) | 0 | 12 (8.6) |
| polycystic kidney disease | 5 (11.1) | 0 | 1 (6.7) | 0 | 0 | 0 | 1 (6.7) | 1 (6.7) | 8 (5.8) |
| urologic | 3 (6.7) | 0 | 0 | 1 (6.7) | 0 | 0 | 0 | 0 | 4 (2.9) |
| autoimmune disease | 1 (2.2) | 0 | 0 | 0 | 1 (6.7) | 0 | 0 | 1 (6.7) | 3 (2.2) |
| unknown | 6 (13.3) | 0 | 0 | 2 (13.3) | 3 (20.0) | 1 (25.0) | 3 (20.0) | 2 (13.3) | 17 (12.2) |
| othera | 9 (20.0) | 8 (53.3) | 5 (33.3) | 6 (40.0) | 3 (20.0) | 1 (25.0) | 2 (13.3) | 6 (40.0) | 40 (28.8) |
| eGFR, mean (SD), ml/min per 1.73 m2 | 24.4 (8.3) | 26.9 (9.8) | 25.7 (14.2) | 25.7 (8.9) | 24.9 (10.7) | 17.8 (5.6) | 25.5 (6.8) | 25.3 (12.9) | 25.0 (9.8) |
| Hemoglobin, mean (SD), g/dl | 10.3 (0.5) | 10.2 (0.5) | 10.2 (0.5) | 10.0 (0.5) | 10.1 (0.5) | 10.3 (0.4) | 10.1 (0.7) | 10.1 (0.6) | 10.2 (0.5) |
SC, subcutaneous; Q4W, every 4 weeks; IV, intravenous; Q2W, every 2 weeks; CKD, chronic kidney disease; eGFR, estimated GFR.
a
Mainly included interstitial nephritis or renovascular disease.