Table 3.
Hemoglobin parameters, by cohort: hemoglobin response, rapid rates of increased hemoglobin, and hemoglobin excursions
| Hemoglobin Parameter, n (%) | Cohort A (0.05 mg/kg SC Q4W n = 45) | Cohort B (0.075 mg/kg SC Q4W n = 15) | Cohort C (0.025 mg/kg SC Q4W n = 15) | Cohort D (0.05 mg/kg IV Q4W n = 15) | Cohort E (0.025 mg/kg SC Q2W n = 15) | Cohort F (0.0375 mg/kg SC Q2W n = 4) | Cohort G 4.0 mg (SC Q4W n = 15) | Cohort H (3.0 mg SC Q4W n = 15) | Total (n = 139) |
|---|---|---|---|---|---|---|---|---|---|
| Patients who achieved a Hb response | 44 (97.8) | 15 (100.0) | 15 (100.0) | 14 (93.3) | 14 (93.3) | 4 (100.0) | 13 (86.7) | 14 (93.3) | 133 (95.7) |
| Patients with >1 g/dl Hb increase during any 2-week perioda | 31 (68.9) | 13 (86.7) | 9 (60.0) | 11 (73.3) | 13 (86.7) | 3 (75.0) | 12 (80.0) | 11 (73.3) | 103 (74.1) |
| Patients with >2 g/dl Hb increase during any 4-week perioda | 12 (26.7) | 3 (20.0) | 0 (0) | 5 (33.3) | 12 (80.0) | 1 (25.0) | 4 (26.7) | 3 (20.0) | 40 (28.8) |
| Patients with Hb excursionsa,b | 6 (13.3) | 1 (6.7) | 0 (0) | 2 (13.3) | 5 (33.3) | 1 (25.0) | 1 (6.7) | 1 (6.7) | 17 (12.2) |
SC, subcutaneous; Q4W, every 4 weeks; IV, intravenous; Q2W, every 2 weeks; Hb, hemoglobin.
a
During the first 8 weeks of the study.
b
Hemoglobin concentrations >13 g/dl on at least two consecutive measurements.