Table 1.
Baseline characteristics of 9384 dialysis patients who underwent renal transplantation between July 2001 and June 2006
| Pretransplant Serum Phosphorus Level (mg/dl) | <3.5 | 3.5 to <5.5 | 5.5 to <7.5 | 7.5 to <9.5 | ≥9.5 | P for Trend |
|---|---|---|---|---|---|---|
| N [%] | 270 [3] | 3700 [40] | 3980 [42] | 1229 [13] | 205 [2] | N/A |
| Age (years) | 53 ± 14 | 51 ± 13 | 47 ± 13 | 42 ± 13 | 37 ± 12 | <0.001 |
| Gender (% women) | 34 | 40 | 36 | 35 | 37 | 0.003 |
| Race (% African American) | 32 | 28 | 28 | 24 | 16 | <0.001 |
| Diabetes mellitus (%) | 35 | 39 | 35 | 30 | 22 | <0.001 |
| BMI (kg/m2) | 25.3 ± 5.3 | 26.2 ± 5.8 | 26.8 ± 5.8 | 27.0 ± 5.7 | 27.0 ± 6.9 | <0.001 |
| Presence of ischemic heart disease (%) | 12 | 10 | 8 | 6 | 7 | <0.001 |
| Presence of congestive heart failure (%) | 14 | 10 | 10 | 9 | 8 | 0.02 |
| Presence of hypertension (%) | 76 | 77 | 77 | 74 | 71 | 0.03 |
| Presence of cerebrovascular events (%) | 4 | 3 | 3 | 2 | 1 | 0.005 |
| Presence of peripheral vascular disease (%) | 6 | 5 | 4 | 3 | 2 | 0.002 |
| Presence of chronic obstructive pulmonary disease (%) | 2 | 1 | 1 | 1 | 0 | 0.10 |
| Presence of cancer (%) | 4 | 2 | 1 | 2 | 2 | 0.05 |
| Tobacco use (%) | 4 | 3 | 4 | 5 | 5 | 0.01 |
| Dialysis vintage (%) | ||||||
| 0 to 6 months | 9 | 11 | 12 | 11 | 13 | 0.51 |
| 6 to 24 months | 25 | 29 | 26 | 23 | 26 | <0.001 |
| 2 to 5 years | 33 | 37 | 36 | 39 | 37 | 0.49 |
| >5 years | 32 | 22 | 25 | 28 | 25 | 0.01 |
| Kt/V | 1.71 ± 0.38 | 1.65 ± 0.36 | 1.59 ± 0.35 | 1.53 ± 0.33 | 1.46 ± 0.31 | <0.001 |
| nPCR (g/kg per day) | 0.98 ± 0.29 | 1.01 ± 0.26 | 1.06 ± 0.25 | 1.12 ± 0.25 | 1.15 ± 0.25 | <0.001 |
| Serum creatinine (mg/dl) | 8.9 ± 3.5 | 9.6 ± 3.1 | 10.9 ± 3.0 | 12.1 ± 3.0 | 12.9 ± 3.2 | <0.001 |
| Serum albumin (mg/dl) | 3.9 ± 0.5 | 4.0 ± 0.4 | 4.0 ± 0.4 | 4.0 ± 0.4 | 4.0 ± 0.4 | <0.001 |
| Serum calcium (mg/dl) | 9.4 ± 0.7 | 9.5 ± 0.7 | 9.5 ± 0.8 | 9.3 ± 0.9 | 9.0 ± 0.9 | <0.001 |
| Blood hemoglobin (g/dl) | 11.8 ± 1.5 | 12.1 ± 1.3 | 12.3 ± 1.2 | 12.3 ± 1.3 | 12.3 ± 1.4 | <0.001 |
| iPTH (pg/ml) | 293 ± 277 | 305 ± 314 | 411 ± 394 | 552 ± 549 | 425 ± 303 | <0.001 |
| WBC (× 103/L) | 6.9 ± 2.3 | 6.8 ± 2.1 | 6.8 ± 2.0 | 7.2 ± 2.1 | 7.5 ± 2.4 | <0.001 |
| Number of HLA mismatch | 3.9 ± 1.8 | 3.6 ± 1.9 | 3.6 ± 1.8 | 3.5 ± 1.8 | 3.2 ± 1.9 | 0.01 |
| Number of HLA-DR mismatch | 1.16 ± 0.74 | 1.06 ± 0.74 | 1.06 ± 0.74 | 1.07 ± 0.74 | 0.96 ± 0.71 | 0.14 |
| PRA (%) | 10 ± 24 | 9 ± 22 | 10 ± 24 | 12 ± 27 | 13 ± 28 | 0.01 |
| PRA >20% (%) | 14 | 13 | 14 | 18 | 17 | 0.002 |
| Donor age (years) | 39 ± 15 | 40 ± 15 | 39 ± 15 | 37 ± 15 | 38 ± 13 | <0.001 |
| Donor gender (% women) | 49 | 46 | 48 | 47 | 51 | 0.30 |
| Donor type (% living) | 26 | 32 | 34 | 34 | 47 | <0.001 |
| EDC kidney (%)a | 23 | 21 | 18 | 14 | 9 | <0.001 |
| Cold ischemia time (hours)a | 17.8 ± 8.3 | 18.1 ± 8.3 | 17.9 ± 8.3 | 17.6 ± 7.7 | 17.6 ± 8.3 | 0.25 |
Data are presented mean ± SD. N/A, not applicable. BMI, body mass index; nPCR, normalized protein catabolic rate; iPTH, intact parathyroid hormone; WBC, white blood cell count; RA, panel reactive antibody (last value prior to transplant). EDC, extended donor criteria.
a
In recipients who received a kidney from deceased donors.