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. 2012 May 24;3:84. doi: 10.3389/fneur.2012.00084

Figure 4.

Figure 4

Resveratrol prevents neuronal loss and delays visual decline. (A) The average degree of pupillary constriction in response to flashes of light measured by pupillometry decreased over the first 2 weeks after immunization in EAE mice, with no difference between EAE mice treated with PBS, 100 mg/kg RSV, 250 mg/kg RSV, or 250 mg/kg SRT501. (B) Visual function, measured by OKR responses, was significantly reduced in EAE mice treated with PBS as compared to those treated with either 100 mg/kg RSV, 250 mg/kg RSV, or 250 mg/kg SRT501 at 2 weeks post-immunization (*p < 0.05). (C) At day 30 post-immunization, there was a significance decrease in the number of RGCs counted in each retina of EAE mice treated with PBS (vehicle) alone, as compared to control, non-EAE mice, and compared to EAE mice treated with RSV or SRT501 (*p < 0.05).