Figure 10.

Schematic diagram of the relation between plasma membrane Ca²⁺ channels, BK, and SK potassium channels and endoplasmic reticulum RY receptors in primary vagal afferent neurons. Single APs evoke Ca²⁺ influx through L and N type VDCCs. Ca²⁺ influx through either of these channels can trigger release of Ca²⁺ from the endoplasmic reticulum via RY receptors. Whereas BK channels are activated directly by Ca²⁺ entering the neuron via N type VDCC, SK channels are activated indirectly. SK channels require Ca²⁺ from CICR pools released after Ca²⁺ influx through N type channels.