Figure 7.

Effect of DBHQ, a functional CICR inhibitor, on the AP- induced Ca²⁺ transient and on the AHP_slow recorded simultaneously in an acutely isolated rabbit nodose neuron. Upper traces represent superimposed Ca²⁺ transients evoked by a train of four APs (10 Hz) recorded in control Locke solution and 7 min after switching to Locke solution containing 10 μM DBHQ. The lower pair of traces shows AHP_slow. DBHQ treatment completely blocked both the Ca²⁺ transient and the AHP_slow. Resting [Ca²⁺]_i was 91 nM. Fluorescence data were acquired at 10 Hz. Resting membrane potential was −67 mV. AP amplitudes are truncated. Data are from ref. 19 with permission from the American Physiological Society.