Fig. 5.

Effects of calcitriol and dietary vitamin D₃ on estrone and estradiol levels in BCa pre and postmenopausal xenografts and surrounding mammary fat pads. Vehicle [control (Con)], calcitriol (Cal), or dietary vitamin D₃ (Vit D) administered to intact female mice representing the premenopausal model (Pre) and to OVX mice receiving androstenedione supplements representing the postmenopausal model (Post) bearing BCa xenografts as described in Fig. 1. Estrone and estradiol levels were determined in extracts of tumors in the premenopausal model (A) and in tumor and mammary fat extracts in the postmenopausal model (B and C) as described in Materials and Methods. Values represent mean ± se from five to 10 determinations. **, P < 0.01 compared with control.