Table 1.
Summary of the effects of hypo- and hyperthyroidism and D3 or D2 deficiencies on the expression of cerebral cortex genes
| Positive genes |
Fold enrichment in cell type |
Fold change |
||||||
|---|---|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Astro | Neuron | Hypo | Hyper | Dio3 KO | Dio3 KO+T3 | Dio2 KO |
| Abcd2 | ATP-binding cassete, subfamily D, member 2 | 18 | −1.9 | 1.3 | nc | 1.5 | nc | |
| Afap1l1 | Actin filament-associated protein 1 | −2.4 | nc | nc | nc | nc | ||
| Aldh1a1 | Aldehyde dehydrogenase family 1, subfamily A1 | 13 | −6.3 | 1.6 | nc | 2.0 | nc | |
| Cbr2 | Carbonyl reductase 2 | −4.8 | 1.8 | nc | 1.5 | nc | ||
| Cntn2 | Contactin 2 (TAG-1) | 5 | −1.9 | nc | nc | nc | nc | |
| Flywch2 | FLYWCH family member 2 | 3 | −1.7 | 1.5 | nc | 2.8 | nc | |
| Gls2 | Glutaminase 2 | 14 | −2.4 | 1.3 | 1.2 | 1.5 | nc | |
| Hr | Hairless | −6.3 | 2.2 | nc | 4.7 | nc | ||
| Luzp1 | Leucine zipper protein 1 | −1.7 | nc | nc | nc | nc | ||
| Nefh | Neurofilament, heavy polypeptide | 37 | −1.9 | nc | nc | nc | nc | |
| Nefm | Neurofilament, medium polypeptide | 83 | −2.4 | nc | nc | nc | nc | |
| Rbm3 | RNA binding motif protein 3 | −2.4 | nc | nc | nc | −2.0 | ||
| Ier5 | Immediate early response 5 | −3.2 | nc | 1.2 | 1.6 | nc | ||
| Itga7 | Integrin α7 | 3 | −2.1 | 1.2 | nc | 1.6 | nc | |
| Itih3 | Inter-α trypsin inhibitor, heavy chain 3 | −2.1 | 2.0 | nc | 3.5 | nc | ||
| Kcnj10 | Potassium inwardly rectifying channel, subfamily J, member 10 | 3 | −4.8 | 1.5 | nc | 2.6 | −1.6 | |
| Paqr6 | Progestin and adipoQ receptor family member VI | 6 | −2.1 | 1.5 | nc | 2.1 | nc | |
| Ppm2c | Pyruvate dehyrogenase phosphatase catalytic subunit 1 | 4 | −2.1 | nc | nc | 1.5 | nc | |
| Sema7a | Semaphorin 7A | 5 | −2.7 | 1.2 | nc | 1.4 | nc | |
| Shh | Sonic hedgehog | 5 | −2.1 | 1.5 | nc | 3.5 | −1.6 | |
| Stac2 | SH3 and cysteine rich domain 2 | −3.2 | nc | nc | nc | nc | ||
| Stard4 | StAR-related lipid transfer (START) domain containing 4 | −2.1 | nc | nc | nc | nc | ||
This is a summary of changes in expression of positive genes as measured by qPCR. Genes of enriched expression more than 3-fold in astrocytes or neurons are indicated. Values for enrichment were obtained from the published database by Cahoy et al. (35). nc, No change.