Fig. 4.
CNTF signaling in leptin-responsive neurons is not required for the anorectic response to CNTF in HFD-fed mice. A, Disruption of CNTFR signaling in leptin-responsive neurons does not affect the anorectic response to CNTFAxo in HFD-fed mice: effect of CNTFAxo on 24-h food intake, P < 0.0001 in CON mice, P < 0.001 in KO mice; interaction of genotype and treatment, P = 0.6289. ***, P < 0.001. B, The 24-h body weight change after CNTFAxo treatment is unaltered by genotype: effect of CNTFAxo, P < 0.01 in both CON and KO mice; interaction of genotype and treatment, P = 0.8218. **, P < 0.01; ***, P < 0.001.