Effects of NK3-SAP injections in the lateral hypothalamus on serum LH (A), FSH (B), and body weight (C). Rats were ovariectomized and injected with NK3-SAP or Blank-SAP on d 0, given E2 capsules 20–23 d later (shown as d 22), and killed after 11 d of E2. A–C, There were no significant differences between rats with lateral hypothalamic NK3-SAP and Blank-SAP injections (mean ± sem, n = 4 values/group, except n = 2 for Blank-SAP gonadotropin levels). +, Significantly different from intact values on d 0, P < 0.05; *, significantly different after E2 (vs. OVX), P < 0.05.