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. 2012 May 2;32(18):6288–6294. doi: 10.1523/JNEUROSCI.4673-11.2012

Figure 3.

Figure 3.

LPS-induced working memory deficits and cholinergic dependence. A, T-maze alternation of PBS or saporin-lesioned animals challenged intraperitoneally with LPS (100 μg/kg) or sterile saline 40 ± 2 d after surgery (n: PBS + sal, 9; PBS + LPS, 6; SAP + sal, 19; SAP + LPS, 10). Bonferroni post hoc tests after significant two-way repeated-measures ANOVA are indicated by ***p < 0.001 and *p < 0.05. B, Cholinergic dependence of T-maze performance was verified by testing 1 h postsystemic challenge with scopolamine hydrobromide (1 mg/kg, i.p., n = 10) or saline (n = 13). Significant interaction between time and treatment by repeated-measures ANOVA is indicated by **p < 0.01. C, Working memory deficits 3 h post-LPS (100 μg/kg) were partially protected against by the acetylcholinesterase inhibitor donepezil (1 mg/kg, i.p.), administered 1 h after LPS. Statistically significant differences by Bonferroni post hoc test after significant main effects by repeated-measures ANOVA are denoted by *p < 0.05 (p75-sap + donepezil n = 14; p75-sap + LPS n = 16; p75-sap + LPS + donepezil n = 8).